2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W700465
    Etodolac acyl glucuronide
    Etodolac acyl glucuronide is a metabolite of the non-steroidal anti-inflammatory compound Etodolac (HY-76251).
    Etodolac acyl glucuronide
  • HY-W013886
    Captopril EP Impurity J
    Captopril EP Impurity J is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM).
    Captopril EP Impurity J
  • HY-124542
    5-Hydroxydiclofenac
    5-Hydroxydiclofenac is a major metabolite of Diclofenac (HY-15036). 5-Hydroxydiclofenac is formed by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C189, CYP2C19, and CYP2C8. 5-Hydroxydiclofenac shows apoptotic effects in hepatocytes.
    5-Hydroxydiclofenac
  • HY-160251
    3-HC-Gluc
    3-HC-Gluc ((3’R,5k’s)-trans-3’ -Hydroxycotinine glucuronide) The trans-structure of 3-HC, the main metabolite of nicotine.
    3-HC-Gluc
  • HY-158623
    (±)13(14)-DiHDPA
    (±)13(14)-DiHDPA ((±)13,14-DiHDPE) a metabolite of Docosahexaenoic acid (DHA; HY-B2167) by P450 (CYP) metabolic pathways.
    (±)13(14)-DiHDPA
  • HY-131396
    α-Hydroxy Montelukast
    α-Hydroxy Montelukast (M7) is a metabolite of Montelukast (HY-13315A).
    α-Hydroxy Montelukast
  • HY-118133
    4'-Hydroxy flurbiprofen
    4'-Hydroxy flurbiprofen is an oxidative metabolite of Flurbiprofen (HY-10582) via the cytochrome P450 enzyme system. 4'-Hydroxy flurbiprofen inhibits COX-1 by 94% at a concentration of 1000 µM.
    4'-Hydroxy flurbiprofen
  • HY-G0011S
    Netupitant N-oxide-d6
    Netupitant N-oxide-d6 is the deuterium labeled Netupitant N-oxide, which is a metabolite of Netupitant.
    Netupitant N-oxide-d<sub>6</sub>
  • HY-131630
    O-Desmethylmetoprolol
    O-Desmethylmetoprolol is the metabolite of Metoprolol (HY-17503) produced by CYP2D6 enzyme metabolism.
    O-Desmethylmetoprolol
  • HY-125559
    Jesaconitine
    Jesaconitine is a toxic alkaloid. Jesaconitine can be derived from Aconitum. Jesaconitine is one of the major metabolites that can be detected in the blood of the right atrium after aconitum poisoning. Various types of arrhythimia are characteristic in aconitine intoxication.
    Jesaconitine
  • HY-171238
    Dihydroechinofuran
    Dihydroechinofuran is an abenzoquinone metabolite.
    Dihydroechinofuran
  • HY-149504
    3-Hydroxy darifenacin
    3-Hydroxy darifenacin is a metabolite of Darifenacin (HY-A0033). 3-Hydroxy darifenacin is an antagonist of M1-5 muscarinic receptors with Kis values of 17.78, 79.43, 2.24, 36.31 and 6.17 nM, respectively in CHO cells.
    3-Hydroxy darifenacin
  • HY-W587489
    RL-603
    RL-603 is the metabolite of Anagrelide (HY-B0523). RL-603 exhibits platelet-lowering activity in mouse model.
    RL-603
  • HY-W753141
    p,p'-DDE-13C12
    p,p'-DDE-13C12 is 13C labeled p,p'-DDE. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM.
    p,p'-DDE-<sup>13</sup>C<sub>12</sub>
  • HY-169878
    CNJ-294
    CNJ-294 is an intermediate in the synthesis of Capmatinib (HY-13404) and a metabolite of Capmatinib (HY-13404).
    CNJ-294
  • HY-131270R
    Febuxostat impurity 8 (Standard)
    Febuxostat impurity 8 (Standard) is the analytical standard of Febuxostat impurity 8. This product is intended for research and analytical applications. Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat impurity 8 (Standard)
  • HY-10873R
    N-Desethyl Sunitinib (Standard)
    N-Desethyl Sunitinib (Standard)
  • HY-W803860
    N-Depropylpropafenone
    N-Depropylpropafenone is an active metabolite of Propafenone (HY-B0432), generated through the CYP450 enzyme system (mainly CYP2D6). It functions by blocking sodium ion channels, slowing myocardial conduction and exhibiting certain antiarrhythmic effects.
    N-Depropylpropafenone
  • HY-W741491
    6-O-Demethyl griseofulvin
    6-O-Demethyl griseofulvin is a metabolite of Griseofulvin (HY-17583).
    6-O-Demethyl griseofulvin
  • HY-137769
    Captopril EP Impurity C
    Captopril EP Impurity C is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM).
    Captopril EP Impurity C
Cat. No. Product Name / Synonyms Application Reactivity